Gluconeogenesis is one of the key metabolic pathways covered in the MCAT. This article includes videos on the core steps and regulation of Gluconeogenesis and Glycolysis.
Gluconeogenesis is the synthesis of glucose from pyruvate and related compounds. In animals, this process occurs primarily in the liver. In many ways, gluconeogenesis is the opposite of glycolysis. glycolysis takes a molecule of glucose and breaks it down into two pyruvate molecules, whereas gluconeogenesis takes two pipe of a molecules and makes glucose. However, the two processes are not complete opposites of each other.
Topics covered: Each step of gluconeogenesis and glycolysis – seven reversible and three not. Diagrams for both reactions and review of all applicable enzymes.
These two pathways are reciprocally regulated. This means that situations that activate one pathway inhibit the other pathway.
Topics covered: How two energy intensive pathways – gluconeogenesis and glycolysis – are regulated to not run simultaneously.
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